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感染新城疫病毒或脑心肌炎病毒或用嘌呤霉素处理的HeLa细胞脱氧核糖核酸的修复复制

Repair replication of HeLa cell deoxyribonucleic acid in cells infected with Newcastle disease virus or mengovirus or treated with puromycin.

作者信息

Hand R, Tamm I

出版信息

J Virol. 1971 Oct;8(4):597-600. doi: 10.1128/JVI.8.4.597-600.1971.

DOI:10.1128/JVI.8.4.597-600.1971
PMID:4331658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC376235/
Abstract

We examined repair replication of HeLa cell deoxyribonucleic acid (DNA) in cells infected with mengovirus or Newcastle disease virus or treated with puromycin. Cellular DNA was damaged by ultraviolet light and then pulse-labeled with (3)H-thymidine. Autoradiographic analysis of non-S-phase DNA synthesis (repair replication) showed that there was no inhibition of this process at a time when overall cellular DNA synthesis was severely inhibited by either virus infection or puromycin treatment.

摘要

我们检测了感染脑心肌炎病毒或新城疫病毒或用嘌呤霉素处理的海拉细胞脱氧核糖核酸（DNA）的修复复制情况。细胞DNA经紫外线损伤，然后用³H-胸腺嘧啶进行脉冲标记。对非S期DNA合成（修复复制）的放射自显影分析表明，在病毒感染或嘌呤霉素处理严重抑制总体细胞DNA合成的同时，这一过程并未受到抑制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7c/376235/76fb9df8da34/jvirol00286-0245-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7c/376235/76fb9df8da34/jvirol00286-0245-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7c/376235/76fb9df8da34/jvirol00286-0245-a.jpg

相似文献

1
Repair replication of HeLa cell deoxyribonucleic acid in cells infected with Newcastle disease virus or mengovirus or treated with puromycin.感染新城疫病毒或脑心肌炎病毒或用嘌呤霉素处理的HeLa细胞脱氧核糖核酸的修复复制
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2
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本文引用的文献

1
STUDIES ON THE MECHANISM OF POLIOVIRUS-INDUCED CELL DAMAGE. I. THE RELATION BETWEEN POLIOVIRUS,-INDUCED METABOLIC AND MORPHOLOGICAL ALTERATIONS IN CULTURED CELLS.脊髓灰质炎病毒所致细胞损伤机制的研究。I. 脊髓灰质炎病毒诱导的培养细胞代谢与形态学改变之间的关系。
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Biochemical basis for alterations in structure and function of HeLa cells infected with Newcastle disease virus.
感染新城疫病毒的海拉细胞结构与功能改变的生化基础。
J Exp Med. 1961 Nov 1;114(5):617-32. doi: 10.1084/jem.114.5.617.
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Patterns of macromolecular synthesis in normal and virus-infected mammalian cells.正常及病毒感染的哺乳动物细胞中大分子合成的模式
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Radiation-stimulated DNA synthesis in cultured mammalian cells.培养的哺乳动物细胞中辐射刺激的DNA合成
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Defective repair replication of DNA in xeroderma pigmentosum.着色性干皮病中DNA修复复制缺陷。
Nature. 1968 May 18;218(5142):652-6. doi: 10.1038/218652a0.
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Spontaneous unscheduled DNA synthesis in GI HeLa cells.
Nature. 1969 Nov 22;224(5221):803-4. doi: 10.1038/224803a0.
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Temperature dependence of thymidine uptake and ability of thymidine incorporated during unscheduled DNA synthesis in irradiated and unirradiated HeLa cells.照射和未照射的HeLa细胞中胸苷摄取的温度依赖性以及在DNA修复合成过程中掺入胸苷的能力。
Int J Radiat Biol Relat Stud Phys Chem Med. 1970;18(3):277-80. doi: 10.1080/09553007014551101.