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[肿瘤冷冻破坏后的细胞活力]

[Cell viability after cryodestruction of the tumor].

作者信息

Kurliand V A, Arungazyeva V V, Kindzel'skiĭ L P

出版信息

Vopr Onkol. 1979;25(3):34-7.

PMID:433202
Abstract

By histoautoradiography DNA was determined in the Heren carcinoma cells during the first 6 days after cryosurgery of the tumor. During 2.5 days after cryosurgery no labeled cells in the cryodestructed tissue were detected. The DNA synthesizing cells were revealed in separate portions of some tumors 66 hours and longer following cryosurgery. The absence of labeled cells during 66 hours since the moment of cryoexposure indicates the block of DNA synthesis in cryoresistant tumor cells. It evidences that the cells which remained viable after cryosurgery were the cause of the recurrences observed.

摘要

通过组织放射自显影术,在肿瘤冷冻手术后的头6天内对赫伦癌细胞中的DNA进行了测定。冷冻手术后的2.5天内,在冷冻破坏的组织中未检测到标记细胞。在冷冻手术后66小时及更长时间,在一些肿瘤的不同部位发现了DNA合成细胞。自冷冻暴露后66小时内未出现标记细胞,这表明冷冻抗性肿瘤细胞中的DNA合成受阻。这证明冷冻手术后仍存活的细胞是观察到复发的原因。

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