小龙虾神经肌肉接头处递质释放的二元性。
The binomial nature of transmitter release at the crayfish neuromuscular junction.
作者信息
Johnson E W, Wernig A
出版信息
J Physiol. 1971 Nov;218(3):757-67. doi: 10.1113/jphysiol.1971.sp009642.
Abstract
- Transmitter release at excitatory junctions on the opener muscle of the crayfish dactyl was studied by recording junctional potentials with extracellular micro-electrodes.2. At low temperatures, evoked release was dispersed sufficiently in time for potentials produced by individual quanta to be counted, and the mean (m) and variance (sigma(2)) of the quantum content distribution for a series of trials measured directly. These values were used to calculate the average probability of quantal release (p), assuming a binomial distribution.3. For all values of m and p, the observed release pattern (number of 0, 1, 2, 3,... quantal releases during a series of trials) was approximated closely by the corresponding binomial distribution. However, Poisson predictions differed significantly from the observed quantal distribution for values of p > 0.2.
摘要
通过用细胞外微电极记录连接电位，研究了小龙虾指节 opener 肌肉兴奋性连接处的递质释放。
在低温下，诱发释放的时间足够分散，以便对单个量子产生的电位进行计数，并直接测量一系列试验中量子含量分布的均值（m）和方差（sigma(2)）。假设为二项分布，这些值用于计算量子释放的平均概率（p）。
对于 m 和 p 的所有值，观察到的释放模式（一系列试验中 0、1、2、3……量子释放的数量）与相应的二项分布非常接近。然而，当 p > 0.2 时，泊松预测与观察到的量子分布有显著差异。
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J Physiol. 1964 Dec;175(1):81-99. doi: 10.1113/jphysiol.1964.sp007504.
2
The quantal nature of transmission and spontaneous miniature potentials at the crayfish neuromuscular junction.小龙虾神经肌肉接头处传递的量子特性和自发微小电位。
J Physiol. 1961 Mar;155(3):514-29. doi: 10.1113/jphysiol.1961.sp006644.
3
Localization of active spots within the neuromuscular junction of the frog.青蛙神经肌肉接头内活性位点的定位。
J Physiol. 1956 Jun 28;132(3):630-49. doi: 10.1113/jphysiol.1956.sp005554.
4
A further study of the statistical composition on the end-plate potential.关于终板电位统计构成的进一步研究。
J Physiol. 1955 Oct 28;130(1):114-22. doi: 10.1113/jphysiol.1955.sp005397.
5
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J Physiol. 1954 Jun 28;124(3):560-73. doi: 10.1113/jphysiol.1954.sp005129.
6
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8
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