毒液肽对血管紧张素I转换酶的抑制作用。
Inhibition of angiotensin I converting enzyme by venom peptides.
作者信息
Bakhle Y S
出版信息
Br J Pharmacol. 1971 Sep;43(1):252-4. doi: 10.1111/j.1476-5381.1971.tb07176.x.
Abstract
The synthetic analogues of three naturally occurring peptides from the venom of Bothrops jararaca have been tested as inhibitors of angiotensin converting enzyme activity in two systems. They have widely differing absolute potencies but the relative potencies are similar in the two systems. The high inhibitory potency of the nonapeptide is compatible with a non-competitive type of inhibition.
摘要
对三种从巴西矛头蝮蛇毒液中提取的天然存在的肽的合成类似物，在两个系统中作为血管紧张素转换酶活性抑制剂进行了测试。它们的绝对效力差异很大，但在两个系统中的相对效力相似。九肽的高抑制效力与非竞争性抑制类型相符。
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Subcellular distribution and properties of the bradykinin inactivation system in rabbit brain homogenates.
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Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom.从矛头蝮蛇毒中分离缓激肽增强肽。
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