Steeves R A, Fjelde A, Mirand E A
Proc Natl Acad Sci U S A. 1971 Oct;68(10):2391-5. doi: 10.1073/pnas.68.10.2391.
Extracts of cultured human leukemic tissues increased the spleen focus-forming activity of Friend leukemia virus preparations in BALB/c and other partially resistant mice. Such mice carry the Fv-1(b) gene, which inhibits the expression of helper virus indigenous to the Friend virus complex, and allows co-infecting leukemia viruses of mice, cats, or chickens to substitute for the inhibited helper virus and increase the expression of the spleen focus-forming virus. The helper activity of extracts from human leukemic tissues shared several important properties with that associated with known leukemogenic viruses of animals.
培养的人白血病组织提取物可增强BALB/c小鼠和其他部分抗性小鼠体内Friend白血病病毒制剂的脾集落形成活性。这类小鼠携带Fv-1(b)基因，该基因可抑制Friend病毒复合物中固有辅助病毒的表达，并使共同感染的小鼠、猫或鸡的白血病病毒替代被抑制的辅助病毒，从而增加脾集落形成病毒的表达。人白血病组织提取物的辅助活性与已知动物白血病病毒的辅助活性具有若干重要特性。
