某些肾上腺素能阻断剂对交感神经细胞的生长抑制作用（6-羟基多巴胺-小鼠和大鼠-免疫交感神经切除术-化学交感神经切除术-颈上神经节）
Growth inhibition of sympathetic cells by some adrenergic blocking agents (6-hydroxydopamine-mice and rats-immunosympathectomy-chemical sympathectomy-superior cervical ganglion).
作者信息
Angeletti P U, Levi-Montalcini R
出版信息
Proc Natl Acad Sci U S A. 1972 Jan;69(1):86-8. doi: 10.1073/pnas.69.1.86.
Abstract
Treatment of newborn mice and rats with the adrenergic blocking agents, guanethidine and bretylium tosylate, results in massive destruction of immature sympathetic nerve cells. A growth inhibition of the same cells is caused by reserpine. Similarities and differences between the effects elicited by these three ganglion blocking agents and a dopamine analog, 6-hydroxydopamine, are discussed.
摘要
用肾上腺素能阻滞剂胍乙啶和甲苯磺酸溴苄铵处理新生小鼠和大鼠，会导致未成熟的交感神经细胞大量破坏。利血平会引起相同细胞的生长抑制。本文讨论了这三种神经节阻滞剂与多巴胺类似物6-羟基多巴胺所引发效应之间的异同。
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