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Simultaneous determination of diazepam and its metabolies N-desmethyldiazepam, oxydiazepam and oxazepam in plasma and urine of man and dog by means of high-performance liquid chromatography.

作者信息

Vree T B, Baars A M, Hekster Y A, van der Kleijn E, O'Reilly W J

出版信息

J Chromatogr. 1979 Apr 11;162(4):605-14. doi: 10.1016/s0378-4347(00)81842-3.

DOI:10.1016/s0378-4347(00)81842-3
PMID:43333
Abstract
摘要

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Simultaneous determination of diazepam and its metabolies N-desmethyldiazepam, oxydiazepam and oxazepam in plasma and urine of man and dog by means of high-performance liquid chromatography.采用高效液相色谱法同时测定人及犬血浆和尿液中地西泮及其代谢物N-去甲基地西泮、奥沙西泮和氯氮䓬。
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引用本文的文献

1
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Psychopharmacology (Berl). 1980;70(1):89-93. doi: 10.1007/BF00432376.
2
Clinical pharmacokinetics of the newer benzodiazepines.新型苯二氮䓬类药物的临床药代动力学
Clin Pharmacokinet. 1983 May-Jun;8(3):233-52. doi: 10.2165/00003088-198308030-00003.
3
Factors influencing the activity and fate of benzodiazepines in the body.影响苯二氮䓬类药物在体内活性及转归的因素。
Br J Clin Pharmacol. 1981;11 Suppl 1(Suppl 1):85S-98S. doi: 10.1111/j.1365-2125.1981.tb01843.x.
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Clinical pharmacokinetics of oxazepam and lorazepam.奥沙西泮和劳拉西泮的临床药代动力学
Clin Pharmacokinet. 1981 Mar-Apr;6(2):89-105. doi: 10.2165/00003088-198106020-00001.
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The influence of diflunisal on the pharmacokinetics of oxazepam.双氟尼酸对奥沙西泮药代动力学的影响。
Br J Clin Pharmacol. 1985 Sep;20(3):225-34. doi: 10.1111/j.1365-2125.1985.tb05065.x.
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Pharmacokinetics of diazepam and four 3-hydroxy-benzodiazepines in the cat.地西泮及四种3-羟基苯二氮䓬类药物在猫体内的药代动力学
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Drug binding and solubility in milk.
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