1,25-二羟胆钙化醇：组织培养中骨吸收的强效刺激剂。

1,25-dihydroxycholecalciferol: a potent stimulator of bone resorption in tissue culture.

作者信息

Raisz L G, Trummel C L, Holick M F, DeLuca H F

出版信息

Science. 1972 Feb 18;175(4023):768-9. doi: 10.1126/science.175.4023.768.

DOI:10.1126/science.175.4023.768

Abstract

1,25-Dihydroxycholecalciferol (DHCC), isolated from kidney homogenates incubated with 25-hydroxycholecalciferol (HCC), stimulated the release of previously incorporated (45)45Ca from fetal rat bones in organ culture, at concentrations of 10(-10) to 10(-8)M. The dose response curves for 1,25-DHCC and 25-HCC, the parent compound, are parallel, but 1,25-DHCC is about 100 times as potent on a weight basis. Brief exposure to maximum doses of either agent leads to prolonged bone resorption.

摘要

从与25-羟基胆钙化醇（HCC）一起孵育的肾脏匀浆中分离出的1,25-二羟基胆钙化醇（DHCC），在10⁻¹⁰至10⁻⁸M的浓度下，刺激了器官培养中胎鼠骨骼中先前掺入的（45）⁴⁵Ca的释放。1,25-DHCC与其母体化合物25-HCC的剂量反应曲线是平行的，但按重量计算，1,25-DHCC的效力约为25-HCC的100倍。短暂暴露于这两种药物的最大剂量都会导致骨吸收延长。