1,25-二羟胆钙化醇：维生素D3的代谢产物，对无肾大鼠的骨骼有活性作用。
1,25-dihydroxycholecalciferol: metabolite of vitamin D3 active on bone in anephric rats.
作者信息
Holick M F, Garabedian M, DeLuca H F
出版信息
Science. 1972 Jun 9;176(4039):1146-7. doi: 10.1126/science.176.4039.1146.
Nephrectomy prevents completely the bone calcium mobilization response to 25-hydroxycholecalciferol. In contrast it does not prevent this response to 1,25-dihydroxycholecalciferol. Because it is known that the kidney is the site of 1,25-dihydroxycholecalciferol formation, these results provide evidence that 1,25-dihydroxycholecalciferol or a further metabolite thereof and not 25-hydroxycholecalciferol is the metabolically active form of vitamin D(3) responsible for bone calcium mobilization.
肾切除术可完全阻止对25-羟胆钙化醇的骨钙动员反应。相比之下，它并不能阻止对1,25-二羟胆钙化醇的这种反应。由于已知肾脏是1,25-二羟胆钙化醇形成的部位，这些结果提供了证据，表明1,25-二羟胆钙化醇或其进一步的代谢产物而非25-羟胆钙化醇是负责骨钙动员的维生素D(3)的代谢活性形式。
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