夸唑定（MJ1988）对平滑肌的作用。
Actions of quazodine (MJ1988) on smooth muscle.
作者信息
Parratt J R, Winslow E
出版信息
Br J Pharmacol. 1971 Nov;43(3):612-23. doi: 10.1111/j.1476-5381.1971.tb07191.x.
Abstract
- Quazodine (MJ1988; 6,7-dimethoxy-4-ethyl-quinazoline) relaxed a variety of vascular and extravascular smooth muscle preparations and antagonized, non-competitively, several substances which contract smooth muscle.2. This activity was not due to beta-adrenoceptor stimulation or to alpha-adrenoceptor blockade.3. On the rabbit duodenum, the inhibitory effect was qualitatively similar to that of theophylline and was antagonized by the phosphodiesterase potentiator, imidazole.4. The activity of quazodine was similar to, but up to 18 times greater than, that of theophylline and it is suggested that at least part of its activity on vascular and extravascular smooth muscle is due to inhibition of phosphodiesterase.
摘要
喹唑定（MJ1988；6,7-二甲氧基-4-乙基喹唑啉）可舒张多种血管和血管外平滑肌制剂，并非竞争性拮抗几种可使平滑肌收缩的物质。
该活性并非由β-肾上腺素能受体刺激或α-肾上腺素能受体阻断所致。
在兔十二指肠上，其抑制作用在性质上与茶碱相似，并被磷酸二酯酶增强剂咪唑所拮抗。
喹唑定的活性与茶碱相似，但比茶碱高18倍，提示其对血管和血管外平滑肌的活性至少部分归因于磷酸二酯酶的抑制。
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