夸唑定（MJ 1988）对大鼠离体半膈及鸡颈二腹肌收缩的影响。
Effects of quazodine (MJ 1988) on contractions of the isolated hemidiaphragm of the rat and the biventer cervicis muscle of the chick.
作者信息
Nott M W, Winslow E
出版信息
Br J Pharmacol. 1973 Jul;48(3):409-17. doi: 10.1111/j.1476-5381.1973.tb08349.x.
Abstract
- The effects of quazodine and theophylline have been studied on the rat hemidiaphragm and chick biventer cervicis preparations in vitro.2. Theophylline and quazodine enhanced maximal twitches and contractural responses to acetylcholine and carbachol.3. These actions on contractility were exerted directly upon the muscle fibres and were dependent upon the concentration of calcium ions in the bathing solution.4. In addition, quazodine enhanced the neuromuscular blocking activity of tubocurarine, probably by a prejunctional action.5. Theophylline potentiated acetylcholine to a greater extent than it potentiated carbachol thus suggesting that theophylline possesses anticholinesterase activity.
摘要
已在体外对大鼠半膈和鸡颈二腹肌制备物研究了喹唑定和茶碱的作用。
茶碱和喹唑定增强了对乙酰胆碱和卡巴胆碱的最大抽搐和挛缩反应。
这些对收缩性的作用直接作用于肌纤维，并取决于浴液中钙离子的浓度。
此外，喹唑定可能通过节前作用增强了筒箭毒碱的神经肌肉阻滞活性。
茶碱对乙酰胆碱的增强作用比对卡巴胆碱的增强作用更大，因此表明茶碱具有抗胆碱酯酶活性。
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