Serota R G, Roberts R B, Flexner L B
Proc Natl Acad Sci U S A. 1972 Feb;69(2):340-2. doi: 10.1073/pnas.69.2.340.
It has previously been shown that rats trained 5 hr after intracerebral injection of acetoxycycloheximide show a transient amnesia at 24 hr after training. We have tested the possibility that adrenergic stimulants might provide protection from the amnesia. Metaraminol, given either before or after training or before testing, prevents the drug-induced amnesia. D-Amphetamine, injected soon after training, also prevents the amnesia. A model is presented to explain the drug-induced amnesia in terms of both the assumed effect of acetoxycycloheximide on the adrenergic system and prevention of the amnesia by metaraminol and D-amphetamine.
先前的研究表明，在脑内注射乙酰氧基环己酰亚胺5小时后接受训练的大鼠，在训练后24小时会出现短暂性失忆。我们测试了肾上腺素能兴奋剂可能预防这种失忆的可能性。间羟胺在训练前、训练后或测试前给予，均可预防药物诱导的失忆。训练后不久注射的右旋苯丙胺也可预防失忆。本文提出了一个模型，从乙酰氧基环己酰亚胺对肾上腺素能系统的假定作用以及间羟胺和右旋苯丙胺对失忆的预防作用两方面来解释药物诱导的失忆。
