奈非西坦、DM-9384对环己酰亚胺诱导的失忆及胆碱乙酰转移酶活性降低的影响。

Effects of nefiracetam, DM-9384 on amnesia and decrease in choline acetyltransferase activity induced by cycloheximide.

作者信息

Shiotani T, Tohyama K, Murase K, Ishihara S, Kameyama T, Yamasaki T, Hatanaka S, Kojima H, Takasu Y, Nabeshima T

机构信息

Tokyo Research and Development Center, Daiichi Pharmaceutical Co. Ltd., Japan.

出版信息

J Neural Transm Gen Sect. 1992;90(2):103-11. doi: 10.1007/BF01250792.

DOI:10.1007/BF01250792

PMID:1463591

Abstract

The effects of nefiracetam, [N-(2,6-dimethyl-phenyl)-2-(2-oxo-pyrrolidinyl)acetamide, DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre-training administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. It protected against CXM-induced inhibition of choline acetyltransferase activity in the cerebral cortex. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with AChergic neuronal system and enhancing protein synthesis in the brain.

摘要

使用被动回避任务，在环己酰亚胺（CXM）诱导的遗忘动物模型中研究了GABA的环状衍生物奈非西坦[N-(2,6-二甲基苯基)-2-(2-氧代吡咯烷基)乙酰胺，DM-9384]的作用。如降低潜伏期的延长所示，DM-9384的预训练给药减轻了CXM诱导的遗忘。它可防止CXM诱导的大脑皮质胆碱乙酰转移酶活性的抑制。这些结果表明，DM-9384通过与胆碱能神经系统相互作用并增强大脑中的蛋白质合成来减轻CXM诱导的遗忘。