秋水仙碱、长春碱或细胞松弛素B对交感神经中多巴胺-β-羟化酶和去甲肾上腺素释放的抑制作用（下腹神经刺激-胞吐作用-微管-微丝-豚鼠）
Inhibition of release of dopamine- -hydroxylase and norepinephrine from sympathetic nerves by colchicine, vinblastine, or cytochalasin-B (hypogastric nerve stimulation-exocytosis-microtubules-microfilaments-guinea pig).
作者信息
Thoa N B, Wooten G F, Axelrod J, Kopin I J
出版信息
Proc Natl Acad Sci U S A. 1972 Feb;69(2):520-2. doi: 10.1073/pnas.69.2.520.
Abstract
Stimulation of the hypogastric nerve to the guinea pig vas deferens in the presence of phenoxybenzamine produced an enhanced release of both dopamine-beta-hydroxylase (EC 1.14.2.1) and norepinephrine. Addition of colchicine, vinblastine, or cytochalasin-B to the incubation medium caused an almost complete inhibition of release of both the amine and the enzyme. Colchicine and cytochalasin-B produced a blocking effect but did not, however, modify the ratio of dopamine-beta-hydroxylase to norepinephrine recovered in the bath fluid. The findings indicate that norepinephrine and dopamine-beta-hydroxylase are released from sympathetic nerve terminals by exocytosis and that this process is dependent upon the integrity of both microtubules and microfilaments.
摘要
在苯氧苄胺存在的情况下，刺激豚鼠输精管的腹下神经会导致多巴胺-β-羟化酶（EC 1.14.2.1）和去甲肾上腺素的释放增加。向孵育培养基中添加秋水仙碱、长春花碱或细胞松弛素B几乎完全抑制了胺和酶的释放。秋水仙碱和细胞松弛素B产生了阻断作用，但并未改变浴液中回收的多巴胺-β-羟化酶与去甲肾上腺素的比例。这些发现表明，去甲肾上腺素和多巴胺-β-羟化酶通过胞吐作用从交感神经末梢释放，并且这一过程依赖于微管和微丝的完整性。
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Inhibition of release of dopamine- -hydroxylase and norepinephrine from sympathetic nerves by colchicine, vinblastine, or cytochalasin-B (hypogastric nerve stimulation-exocytosis-microtubules-microfilaments-guinea pig).秋水仙碱、长春碱或细胞松弛素B对交感神经中多巴胺-β-羟化酶和去甲肾上腺素释放的抑制作用（下腹神经刺激-胞吐作用-微管-微丝-豚鼠）
Proc Natl Acad Sci U S A. 1972 Feb;69(2):520-2. doi: 10.1073/pnas.69.2.520.
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