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相似文献

1
Inhibition of release of dopamine- -hydroxylase and norepinephrine from sympathetic nerves by colchicine, vinblastine, or cytochalasin-B (hypogastric nerve stimulation-exocytosis-microtubules-microfilaments-guinea pig).秋水仙碱、长春碱或细胞松弛素B对交感神经中多巴胺-β-羟化酶和去甲肾上腺素释放的抑制作用（下腹神经刺激-胞吐作用-微管-微丝-豚鼠）
Proc Natl Acad Sci U S A. 1972 Feb;69(2):520-2. doi: 10.1073/pnas.69.2.520.
2
Proportional release of norepinephrine and dopamine- -hydroxylase from sympathetic nerves.去甲肾上腺素和多巴胺-β-羟化酶从交感神经的比例释放。
Science. 1971 Dec 24;174(4016):1349-51. doi: 10.1126/science.174.4016.1349.
3
Enhanced release of dopamine- -hydroxylase from sympathetic nerves by calcium and phenoxybenzamine and its reversal by prostaglandins.钙和酚苄明促使交感神经中多巴胺-β-羟化酶的释放增加，而前列腺素可使其释放逆转。
Proc Natl Acad Sci U S A. 1971 Sep;68(9):2227-30. doi: 10.1073/pnas.68.9.2227.
4
Effects of colchicine and vinblastine on axonal transport and transmitter release in sympathetic nerves.秋水仙碱和长春碱对交感神经轴突运输和递质释放的影响。
Ann N Y Acad Sci. 1975 Jun 30;253:528-34. doi: 10.1111/j.1749-6632.1975.tb19226.x.
5
Enhanced release of dopamine -hydroxylase and norepinephrine from sympathetic nerves by dibutyryl cyclic adenosine 3', 5'-monophosphate and theophylline.二丁酰环磷腺苷和茶碱促使交感神经增强释放多巴胺-β-羟化酶和去甲肾上腺素。
Mol Pharmacol. 1973 Mar;9(2):178-83.
6
Inhibition by halothane of release of norepinephrine, but not of dopamine-beta-hydroxylase, from guinea-pig vas deferens.氟烷对豚鼠输精管去甲肾上腺素释放的抑制作用，但对多巴胺-β-羟化酶释放无抑制作用。
Eur J Pharmacol. 1975 Apr;31(2):313-8. doi: 10.1016/0014-2999(75)90054-0.
7
Inhibition by cyclopropane of release od norepinephrine, but not dopamine-beta-hydroxylase, from the guinea-pig vas deferens.环丙烷对豚鼠输精管去甲肾上腺素释放的抑制作用，但对多巴胺-β-羟化酶释放无抑制作用。
Anesthesiology. 1976 Jan;44(1):54-6. doi: 10.1097/00000542-197601000-00012.
8
On the mechanism of release of norepinephrine from sympathetic nerves induced by depolarizing agents and sympathomimetic drugs.关于去极化剂和拟交感神经药物诱导交感神经释放去甲肾上腺素的机制
Mol Pharmacol. 1975 Jan;11(1):10-8.
9
Effect of reserpine, phenoxybenzamine and cocaine on neuromuscular transmission in the vas deferens of the guinea pig.利血平、酚苄明和可卡因对豚鼠输精管神经肌肉传递的影响。
J Pharmacol Exp Ther. 1972 May;181(2):310-7.
10
Proceedings: The in vitro effects of vinblastine on the nerve-mediated responses of the guinea-pig vas deferens.论文：长春碱对豚鼠输精管神经介导反应的体外效应
Br J Pharmacol. 1974 Mar;50(3):455P.

引用本文的文献

1
A Hypothesis Regarding Neurosecretory Inhibition of Stress Mediators by Colchicine in Preventing Stress-Induced Familial Mediterranean Fever Attacks.关于秋水仙碱通过神经分泌抑制应激介质预防应激诱发家族性地中海热发作的假说。
Front Immunol. 2022 Feb 17;13:834769. doi: 10.3389/fimmu.2022.834769. eCollection 2022.
2
Depressogenic effects of medications: a review.药物的致抑郁作用：综述
Dialogues Clin Neurosci. 2011;13(1):109-25. doi: 10.31887/DCNS.2011.13.1/ccelano.
3
Investigations into the biochemical basis of neuromodulation by 2-phenylethylamine: effect on microtubule protein.2-苯乙胺对神经调节的生化基础的研究：对微管蛋白的影响。
Neurochem Res. 1993 Dec;18(12):1221-9. doi: 10.1007/BF00975039.
4
Shwachman's syndrome. A review of 21 cases.施瓦赫曼综合征。21例病例综述。
Arch Dis Child. 1980 May;55(5):331-47. doi: 10.1136/adc.55.5.331.
5
Ion-induced release of LHRH, TRH and alpha-MSH from hypothalamic synaptosomes and its inhibition by vinblastine.离子诱导下丘脑突触体释放促黄体生成素释放激素、促甲状腺激素释放激素和α-促黑素以及长春碱对其的抑制作用。
Pflugers Arch. 1980 May;385(1):79-84. doi: 10.1007/BF00583918.
6
Neurotoxicity of acrylamide and related compounds in rats. Effects on rotarod performance, morphology of nerves and neurotubulin.丙烯酰胺及相关化合物对大鼠的神经毒性。对转棒试验表现、神经形态和神经微管蛋白的影响。
Arch Toxicol. 1983 Nov;54(3):203-13. doi: 10.1007/BF01239204.
7
Serotonin binds specifically and saturably to an actin-like protein isolated from rat brain synaptosomes.血清素特异性且可饱和地结合从大鼠脑突触小体分离出的一种肌动蛋白样蛋白。
Proc Natl Acad Sci U S A. 1984 Feb;81(3):959-63. doi: 10.1073/pnas.81.3.959.
8
Proceedings: The in vitro effects of vinblastine on the nerve-mediated responses of the guinea-pig vas deferens.论文：长春碱对豚鼠输精管神经介导反应的体外效应
Br J Pharmacol. 1974 Mar;50(3):455P.
9
Cytochalasin B: inhibition of glucose-induced insulin release from isolated rat pancreatic islets.细胞松弛素B：对分离的大鼠胰岛中葡萄糖诱导的胰岛素释放的抑制作用
Diabetologia. 1974 Feb;10(1):85-7. doi: 10.1007/BF00421418.
10
Regulation of melanophore stimulating hormone (MSH) release.促黑素细胞激素（MSH）释放的调节。
Yale J Biol Med. 1973 Dec;46(5):602-16.

本文引用的文献

1
PROPERTIES OF NOREPINEPHRINE STORAGE PARTICLES OF THE RAT HEART.大鼠心脏去甲肾上腺素储存颗粒的特性
J Pharmacol Exp Ther. 1963 Dec;142:299-305.
2
Electron microscope study of the excretion of cathecol-containing droplets in the adrenal medulla.肾上腺髓质中含儿茶酚胺液滴排泄的电子显微镜研究。
Exp Cell Res. 1957 Jun;12(3):568-74. doi: 10.1016/0014-4827(57)90172-6.
3
Effects of cytochalasins on mammalian cells.细胞松弛素对哺乳动物细胞的影响。
Nature. 1967 Jan 21;213(5073):261-4. doi: 10.1038/213261a0.
4
Isolation of a protein subunit from microtubules.从微管中分离出一种蛋白质亚基。
J Cell Biol. 1967 Aug;34(2):549-54. doi: 10.1083/jcb.34.2.549.
5
Effect of colchicine on transport of amine storage granules in sympathetic nerves of rat.秋水仙碱对大鼠交感神经中胺储存颗粒转运的影响。
Eur J Pharmacol. 1968 Dec;5(1):111-3. doi: 10.1016/0014-2999(68)90165-9.
6
Effects of mitotic spindle inhibitors on neurotubules and neurofilaments in anterior horn cells.有丝分裂纺锤体抑制剂对前角细胞中神经微管和神经丝的影响。
J Cell Biol. 1968 Jul;38(1):224-9. doi: 10.1083/jcb.38.1.224.
7
A possible role of microtubules in catecholamine release from the adrenal medulla: effect of colchicine, vinca alkaloids and deuterium oxide.微管在肾上腺髓质儿茶酚胺释放中的可能作用：秋水仙碱、长春花生物碱和重水的影响
J Pharmacol Exp Ther. 1971 Apr;177(1):102-8.
8
Microfilaments in cellular and developmental processes.细胞与发育过程中的微丝。
Science. 1971 Jan 15;171(3967):135-43. doi: 10.1126/science.171.3967.135.
9
Properties of colchicine binding protein from chick embryo brain. Interactions with vinca alkaloids and podophyllotoxin.鸡胚脑秋水仙碱结合蛋白的特性。与长春花生物碱和鬼臼毒素的相互作用。
Biochemistry. 1970 Dec 8;9(25):4999-5007. doi: 10.1021/bi00827a026.
10
Enhanced release of dopamine- -hydroxylase from sympathetic nerves by calcium and phenoxybenzamine and its reversal by prostaglandins.钙和酚苄明促使交感神经中多巴胺-β-羟化酶的释放增加，而前列腺素可使其释放逆转。
Proc Natl Acad Sci U S A. 1971 Sep;68(9):2227-30. doi: 10.1073/pnas.68.9.2227.

秋水仙碱、长春碱或细胞松弛素B对交感神经中多巴胺-β-羟化酶和去甲肾上腺素释放的抑制作用（下腹神经刺激-胞吐作用-微管-微丝-豚鼠）

Inhibition of release of dopamine- -hydroxylase and norepinephrine from sympathetic nerves by colchicine, vinblastine, or cytochalasin-B (hypogastric nerve stimulation-exocytosis-microtubules-microfilaments-guinea pig).

作者信息

Thoa N B, Wooten G F, Axelrod J, Kopin I J

出版信息

Proc Natl Acad Sci U S A. 1972 Feb;69(2):520-2. doi: 10.1073/pnas.69.2.520.

DOI:10.1073/pnas.69.2.520
PMID:4333989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC426493/
Abstract

Stimulation of the hypogastric nerve to the guinea pig vas deferens in the presence of phenoxybenzamine produced an enhanced release of both dopamine-beta-hydroxylase (EC 1.14.2.1) and norepinephrine. Addition of colchicine, vinblastine, or cytochalasin-B to the incubation medium caused an almost complete inhibition of release of both the amine and the enzyme. Colchicine and cytochalasin-B produced a blocking effect but did not, however, modify the ratio of dopamine-beta-hydroxylase to norepinephrine recovered in the bath fluid. The findings indicate that norepinephrine and dopamine-beta-hydroxylase are released from sympathetic nerve terminals by exocytosis and that this process is dependent upon the integrity of both microtubules and microfilaments.

摘要

在苯氧苄胺存在的情况下，刺激豚鼠输精管的腹下神经会导致多巴胺-β-羟化酶（EC 1.14.2.1）和去甲肾上腺素的释放增加。向孵育培养基中添加秋水仙碱、长春花碱或细胞松弛素B几乎完全抑制了胺和酶的释放。秋水仙碱和细胞松弛素B产生了阻断作用，但并未改变浴液中回收的多巴胺-β-羟化酶与去甲肾上腺素的比例。这些发现表明，去甲肾上腺素和多巴胺-β-羟化酶通过胞吐作用从交感神经末梢释放，并且这一过程依赖于微管和微丝的完整性。