Roizen M F, Thoa N B, Moss J, Kopin I J
Anesthesiology. 1976 Jan;44(1):54-6. doi: 10.1097/00000542-197601000-00012.
Like halothane, cyclopropane reduces stimulation-induced release of norepinephrine, but not release of dopamine-beta-hydroxylase, from the isolated guinea-pig vas deverens. The dissociation between transmitter release and enzyme release in the presence of cyclopropane may be the result of either an increase in the affinity of norepinephrine for binding sites on the vesicular membrane produced by cyclopropane, or a direct effect of cyclopropane on a mechanism of release of norepinephrine that could be controlled independently of release of dopamine-beta-hydroxylase.
与氟烷一样，环丙烷可减少刺激诱导的去甲肾上腺素从离体豚鼠输精管的释放，但不会减少多巴胺-β-羟化酶的释放。在环丙烷存在的情况下，递质释放与酶释放之间的解离可能是由于环丙烷使去甲肾上腺素对囊泡膜上结合位点的亲和力增加，或者是环丙烷对去甲肾上腺素释放机制产生直接影响，而该机制可独立于多巴胺-β-羟化酶的释放进行控制。
