Liggins G C, France J T, Knox B S, Zapol W M
Acta Endocrinol (Copenh). 1979 Apr;90(4):718-26. doi: 10.1530/acta.0.0900718.
Pregnant and non-pregnant Weddell seals and foetuses were found to have very high plasma concentrations of corticosteroids (1--7 mumol/l) that were unaffected by stress. Cortisol comprised most of the corticosteroid in the adult but only 50% of that in the foetus. The affinity constant (4.30-5.53 x 10(7) l/mol) and specificity of CBG and the MCR (4.5 l/d/kg lean body mass) in adult seals were similar to those of Man. The binding capacity of CBG (1.48--1.86 mumol/l) which is approximately three times that of Man contributed to the high plasma corticosteroid concentrations but the main factor was the cortisol turnover rate of 3670 mumol/d (1.3 g/d) which is the highest value reported in any species.
研究发现，怀孕和未怀孕的威德尔海豹及其胎儿的血浆皮质类固醇浓度非常高（1 - 7微摩尔/升），且不受应激影响。皮质醇在成年海豹的皮质类固醇中占大部分，但在胎儿中仅占50%。成年海豹中皮质类固醇结合球蛋白（CBG）的亲和常数（4.30 - 5.53×10⁷升/摩尔）和特异性以及代谢清除率（MCR，4.5升/天/千克去脂体重）与人类相似。CBG的结合能力（1.48 - 1.86微摩尔/升）约为人类的三倍，这导致了血浆皮质类固醇浓度较高，但主要因素是皮质醇周转率为3670微摩尔/天（1.3克/天），这是任何物种中报道的最高值。
