Cherry C P, Glucksmann A
Br J Cancer. 1971 Dec;25(4):746-58. doi: 10.1038/bjc.1971.89.
Castrate female rats given weekly applications of DMBA to the genital tract and treated additionally with growth hormone, insulin or alloxan (to induce diabetes) are heavier and have more sarcomatous and epithelial cervico-vaginal neoplasms than intact animals under the same experimental conditions. Promotion of carcinogenesis and gain in body weight are independent phenomena caused by castration in the medicated rats. Growth hormone is most effective in enhancing body weight in all animals, but least as regards tumour formation. It reduces the incidence of sarcomas in intacts, but raises that of epithelial neoplasms, and promotes both types of neoplasms in castrates. The highest incidence of cervico-vaginal epithelial and sarcomatous tumours occurs in spayed diabetics.Squamous celled epitheliomas of the vulva are not affected by castration or additional medication, while basal celled neoplasms tend to be more frequent in intacts than in castrates and particularly numerous in intact failed diabetics. Vulval sarcomas are usually rare but are increased in numbers in diabetic and in insulin treated intacts.Granular myoblastomas of the cervico-vaginal tract occur in intacts only and particularly in diabetics and those medicated with growth hormone or insulin.
每周对去势雌性大鼠的生殖道涂抹二甲基苯蒽，并额外用生长激素、胰岛素或四氧嘧啶（诱导糖尿病）进行处理，在相同实验条件下，这些大鼠比未处理的动物体重更重，宫颈 - 阴道肉瘤和上皮性肿瘤更多。在用药大鼠中，致癌作用的促进和体重增加是由去势引起的独立现象。生长激素在增加所有动物体重方面最有效，但在肿瘤形成方面效果最差。它降低了未处理动物中肉瘤的发生率，但提高了上皮性肿瘤的发生率，并促进了去势动物中两种类型肿瘤的发生。宫颈 - 阴道上皮和肉瘤性肿瘤的最高发生率出现在去势糖尿病大鼠中。外阴鳞状细胞上皮瘤不受去势或额外用药的影响，而基底细胞瘤在未处理动物中往往比去势动物更常见，在未处理的糖尿病失败大鼠中尤其多。外阴肉瘤通常很少见，但在糖尿病大鼠和接受胰岛素处理的未处理动物中数量增加。宫颈 - 阴道颗粒性成肌细胞瘤仅发生在未处理动物中，尤其在糖尿病大鼠以及用生长激素或胰岛素处理的动物中。
