Mogensen H H
Acta Pathol Microbiol Scand C. 1979 Feb;87C(1):41-5.
In 21 persons with previous typhoid fever and in 15 controls thymidine incorporation of blood lymphocytes stimulated in vitro by killed Salmonella typhi was studied. The optimal culture conditions were established to be a cell density of 10(5) cells per vial, stimulated with 10(8) S. typhi and incubated for 5 days. The lymphocytes response to S. typhi was significantly higher in the typhoid group than in the controls. The lymphocyte responsiveness was not correlated to the time elapsed since the attack, and was not found different in patients who had had typhoid relapse. No difference was found in lymphocyte response to the mitogens PHA, PWM and Con-A between the typhoid group and the controls.
对21例曾患伤寒热的患者及15名对照者，研究了体外经伤寒杆菌灭活疫苗刺激的血淋巴细胞中胸腺嘧啶核苷的掺入情况。确定最佳培养条件为每瓶细胞密度为10⁵个细胞，用10⁸个伤寒杆菌进行刺激，并培养5天。伤寒组淋巴细胞对伤寒杆菌的反应明显高于对照组。淋巴细胞反应性与发病后的时间无关，且伤寒复发患者的淋巴细胞反应性无差异。伤寒组与对照组之间，淋巴细胞对有丝分裂原PHA、PWM和Con - A的反应无差异。
