通过检测血浆17-羟孕酮诊断先天性肾上腺皮质增生症。
Diagnosis of congenital adrenal hyperplasia by measurement of plasma 17-hydroxyprogesterone.
作者信息
Barnes N D, Atherden S M
出版信息
Arch Dis Child. 1972 Feb;47(251):62-5. doi: 10.1136/adc.47.251.62.
Abstract
Measurement of plasma 17-hydroxyprogesterone by a simple competitive protein-binding assay has proved of value in the diagnosis of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Children with untreated adrenal hyperplasia had high resting levels from as early as the 6th day of life, and children treated with suppressive doses of cortisone showed a rise after adrenal stimulation with tetracosactrin. The method also promises to enhance the ease and precision with which the condition can be managed.
摘要
通过一种简单的竞争性蛋白结合测定法来测量血浆17-羟孕酮，已证明在诊断因21-羟化酶缺乏所致的先天性肾上腺增生症方面具有价值。未经治疗的肾上腺增生症患儿早在出生后第6天就有较高的静息水平，而接受抑制剂量可的松治疗的患儿在用二十四肽促皮质素刺激肾上腺后水平会升高。该方法还有望提高对该病症进行管理的便捷性和精确性。
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