缺氧对大鼠肠道辐射诱导纤维化的保护作用。
Protective effect of hypoxia against radiation induced fibrosis in the rat gut.
作者信息
Forsberg J O, Jiborn H, Jung B
出版信息
Acta Radiol Oncol Radiat Phys Biol. 1979;18(1):65-75. doi: 10.3109/02841867909128191.
PMID:433659
Abstract
The protective effect of hypoxia, induced by degradable microspheres, against the development of fibrosis was investigated after single-dose irradiation of exteriorized rat ileum. Evaluation, based upon microscopy and analysis of hydroxyproline in protected and nonprotected gut segments, demonstrated an evident protective effect at doses of 15 to 25 Gy.
摘要
在对大鼠外置回肠进行单剂量照射后，研究了可降解微球诱导的低氧对纤维化发展的保护作用。基于对受保护和未受保护肠段的显微镜检查以及羟脯氨酸分析的评估表明，在15至25 Gy的剂量下有明显的保护作用。
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