人类恶性疾病主动免疫治疗后肿瘤排斥的组织学证据。
Histological evidence of tumour rejection after active immunotherapy in human malignant disease.
作者信息
Taylor G, Odili J L
出版信息
Br Med J. 1972 Apr 22;2(5807):183-8. doi: 10.1136/bmj.2.5807.183.
Abstract
Active immunotherapy with multiple doses of tumour homogenate incorporated in complete Freund adjuvant was used to treat 12 patients with advanced malignant disease. Evidence of some tumour destruction was observed in 10. Improvement in general clinical condition and the disappearance of symptoms referable to tumour occurred in seven of the patients. The duration of improvement varied considerably. Histological evidence of lymphocytic infiltration, necrosis, and fibrous replacement of tumour tissue is presented.
摘要
采用将多剂肿瘤匀浆加入完全弗氏佐剂中的主动免疫疗法治疗12例晚期恶性疾病患者。在10例患者中观察到了一些肿瘤破坏的证据。7例患者的一般临床状况有所改善，与肿瘤相关的症状消失。改善的持续时间差异很大。文中呈现了肿瘤组织淋巴细胞浸润、坏死和纤维替代的组织学证据。
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