• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

人类恶性疾病主动免疫治疗后肿瘤排斥的组织学证据。

Histological evidence of tumour rejection after active immunotherapy in human malignant disease.

作者信息

Taylor G, Odili J L

出版信息

Br Med J. 1972 Apr 22;2(5807):183-8. doi: 10.1136/bmj.2.5807.183.

DOI:10.1136/bmj.2.5807.183
PMID:4336763
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1787938/
Abstract

Active immunotherapy with multiple doses of tumour homogenate incorporated in complete Freund adjuvant was used to treat 12 patients with advanced malignant disease. Evidence of some tumour destruction was observed in 10. Improvement in general clinical condition and the disappearance of symptoms referable to tumour occurred in seven of the patients. The duration of improvement varied considerably. Histological evidence of lymphocytic infiltration, necrosis, and fibrous replacement of tumour tissue is presented.

摘要

采用将多剂肿瘤匀浆加入完全弗氏佐剂中的主动免疫疗法治疗12例晚期恶性疾病患者。在10例患者中观察到了一些肿瘤破坏的证据。7例患者的一般临床状况有所改善，与肿瘤相关的症状消失。改善的持续时间差异很大。文中呈现了肿瘤组织淋巴细胞浸润、坏死和纤维替代的组织学证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a29/1787938/4c4bcaa27b50/brmedj02200-0019-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a29/1787938/2a1f0f7dad8d/brmedj02200-0016-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a29/1787938/884014baffce/brmedj02200-0016-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a29/1787938/54ea64795357/brmedj02200-0017-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a29/1787938/491388556e6c/brmedj02200-0017-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a29/1787938/18f3c55da702/brmedj02200-0017-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a29/1787938/3be0c53c3bdb/brmedj02200-0017-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a29/1787938/d424ea694ccd/brmedj02200-0017-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a29/1787938/6c06f29870bd/brmedj02200-0018-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a29/1787938/70782f074b8c/brmedj02200-0018-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a29/1787938/66a531414a21/brmedj02200-0018-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a29/1787938/6818b9fad6ca/brmedj02200-0018-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a29/1787938/17dc6762f659/brmedj02200-0019-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a29/1787938/4c4bcaa27b50/brmedj02200-0019-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a29/1787938/2a1f0f7dad8d/brmedj02200-0016-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a29/1787938/884014baffce/brmedj02200-0016-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a29/1787938/54ea64795357/brmedj02200-0017-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a29/1787938/491388556e6c/brmedj02200-0017-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a29/1787938/18f3c55da702/brmedj02200-0017-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a29/1787938/3be0c53c3bdb/brmedj02200-0017-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a29/1787938/d424ea694ccd/brmedj02200-0017-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a29/1787938/6c06f29870bd/brmedj02200-0018-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a29/1787938/70782f074b8c/brmedj02200-0018-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a29/1787938/66a531414a21/brmedj02200-0018-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a29/1787938/6818b9fad6ca/brmedj02200-0018-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a29/1787938/17dc6762f659/brmedj02200-0019-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a29/1787938/4c4bcaa27b50/brmedj02200-0019-b.jpg

相似文献

1
Histological evidence of tumour rejection after active immunotherapy in human malignant disease.人类恶性疾病主动免疫治疗后肿瘤排斥的组织学证据。
Br Med J. 1972 Apr 22;2(5807):183-8. doi: 10.1136/bmj.2.5807.183.
2
[New therapeutic experiments in metastasizing melanoma].[转移性黑色素瘤的新治疗实验]
Hippokrates. 1970 Dec;41(4):532-4.
3
[The treatment of melanoma metastases with smallpox vaccine and Freund's adjuvant].
Munch Med Wochenschr. 1970 Oct 16;112(42):1916.
4
[A review of clinical tumor immunology. An approach to immunochemotherapy].[临床肿瘤免疫学综述。免疫化学疗法的一种方法]
Nihon Gan Chiryo Gakkai Shi. 1974 Nov 20;9(4):381-90.
5
[Regression of melanoma metastases after injection of Freund's adjuvant].
Hautarzt. 1970 Apr;21(4):181-3.
6
[Oncolysis in lymph-node metastases of melanoma].[黑色素瘤淋巴结转移中的肿瘤溶解作用]
Dtsch Med Wochenschr. 1970 Nov 27;95(48):2432-3. doi: 10.1055/s-0028-1108848.
7
A study in clinical cancer immunotherapy.一项临床癌症免疫疗法研究。
Cancer. 1970 Aug;26(2):269-78. doi: 10.1002/1097-0142(197008)26:2<269::aid-cncr2820260205>3.0.co;2-x.
8
[Studies on the effect of smallpox vaccine and Freund's adjuvant on the Harding-Passey melanoma in the mouse].[天花疫苗和弗氏佐剂对小鼠哈丁-帕西黑色素瘤影响的研究]
Arch Dermatol Forsch. 1971;241(4):411-25.
9
The use of immunized pig lymph-node cells in the treatment of patients with advanced malignant disease.免疫猪淋巴结细胞在晚期恶性疾病患者治疗中的应用。
Br J Surg. 1973 Mar;60(3):176-80. doi: 10.1002/bjs.1800600303.
10
Immune cytolysis of human tumor cells mediated by xenogeneic "immune" RNA: implications for immunotherapy.异种“免疫”RNA介导的人肿瘤细胞免疫溶解：对免疫治疗的启示
Surgery. 1974 Jul;76(1):23-34.

引用本文的文献

1
Lymphoreticular infiltration in human tumours: prognostic and biological implications: a review.人类肿瘤中的淋巴网状浸润：预后及生物学意义：综述
Br J Cancer. 1974 Dec;30(6):538-48. doi: 10.1038/bjc.1974.233.
2
Leukaemia-associated antigens in man. Detection by antibodies in maternal sera.人类白血病相关抗原。通过母体血清中的抗体进行检测。
Clin Exp Immunol. 1974 Aug;17(4):571-86.
3
Immunology of bronchial carcinoma.支气管癌的免疫学

本文引用的文献

1
The effect of prior injections of tissue antiserums on the survival of cancer homoiografts in mice.预先注射组织抗血清对小鼠体内癌同种移植物存活的影响。
Cancer Res. 1952 Feb;12(2):110-2.
2
The role of the reticuloendothelial system in the host reaction to neoplasia.网状内皮系统在宿主对肿瘤形成的反应中的作用。
Cancer Res. 1961 Oct;21:1281-300.
3
PRELIMINARY OBSERVATIONS ON TREATMENT OF ADVANCED CANCER BY INJECTION OF ALLOGENEIC SPLEEN CELLS.同种异体脾细胞注射治疗晚期癌症的初步观察
Thorax. 1976 Oct;31(5):493-506. doi: 10.1136/thx.31.5.493.
4
[The immunology of malignant melanoma (author's transl)].[恶性黑色素瘤的免疫学（作者译）]
Klin Wochenschr. 1978 Mar 15;53(16):241-53.
5
Tumour immunology and the gut.肿瘤免疫学与肠道
Gut. 1975 Jun;16(6):490-9. doi: 10.1136/gut.16.6.490.
Lancet. 1963 Aug 31;2(7305):426-9. doi: 10.1016/s0140-6736(63)92171-8.
4
The effect of isoantibodies in vivo on three different transplantable neoplasms in mice.体内同种抗体对小鼠三种不同可移植性肿瘤的影响。
Cancer Res. 1959 Sep;19:824-30.
5
Studies in tumor autoimmunity.肿瘤自身免疫研究。
Cancer Res. 1960 Apr;20:351-6.
6
Demonstration of resistance against methylcholanthrene-induced sarcomas in the primary autochthonous host.在原发性本地宿主中对甲基胆蒽诱导的肉瘤产生抗性的证明。
Cancer Res. 1960 Dec;20:1561-72.
7
The effect of vaccine on cancer patients.疫苗对癌症患者的影响。
Surg Gynecol Obstet. 1959 Aug;109(2):131-8.
8
Immunological enhancement of tumor homografts in mice: a review.小鼠肿瘤同基因移植的免疫增强：综述
Cancer Res. 1958 Oct;18(9):992-1003.
9
Experiments in immunity in cancer.癌症免疫实验
Can Med Assoc J. 1958 Aug 15;79(4):249-59.
10
Antigenic properties of methylcholanthrene-induced tumors in mice of the strain of origin.甲基胆蒽诱发的原种系小鼠肿瘤的抗原特性。
Cancer Res. 1953 Dec;13(12):835-7.