Sebring E S, Polesky H F, Schanfield M S
Am J Clin Pathol. 1979 Mar;71(3):281-5. doi: 10.1093/ajcp/71.3.281.
Immunoglobulin allotyping in 925 cases of disputed paternity provided evidence of exclusion for 70 alleged fathers. Combining results from erythrocytic antigen, enzyme, and serum protein tests, 230 men were proven to be falsely accused; in 15 cases the immunoglobulin allotype provided the only evidence for exclusion, in 67 no exclusion would have been identified if testing had been limited to ABO, Rh, and MNSs. Various cases in this study illustrate the importance of using an extensive battery of immunoglobulin reagents in order maximally to exclude falsely accused men, and to identify infrequent haplotypes, which might erroneously be interpreted as indirect exclusions or may indicate a high likelihood of paternity. The problems of Gm typing of very young children are described. When child is less than 6 months of age, direct exclusions may be missed by the Gm allotypes; indirect exclusions are valid only when the phenotype differs from that of the mother. Km allotypes are not age-dependent.
对925例亲权争议案例进行免疫球蛋白同种异型分型，结果显示有70名所谓的父亲被排除。综合红细胞抗原、酶和血清蛋白检测结果，证实有230名男性被误控；在15个案例中，免疫球蛋白同种异型分型提供了唯一的排除证据；在67个案例中，如果检测仅限于ABO、Rh和MNSs，就无法识别出排除情况。本研究中的各种案例表明，使用大量免疫球蛋白试剂的重要性，以便最大限度地排除被误控的男性，并识别罕见单倍型，否则这些单倍型可能被错误地解释为间接排除，或者可能表明亲权关系的可能性很高。文中描述了对非常年幼儿童进行Gm分型的问题。当儿童小于6个月时，Gm同种异型可能会遗漏直接排除情况；间接排除仅在表型与母亲不同时才有效。Km同种异型不依赖于年龄。
