Mitelman F, Mark J, Levan G, Levan A
Science. 1972 Jun 23;176(4041):1340-1. doi: 10.1126/science.176.4041.1340.
Fibrosarcomas induced in Chinese hamsters and rats by Rous sarcomla virus and 7,12-dimethylbenz(a)anthracene are associated with nonrandom chromosome variation. Although histologically indistinguishable, the tumors induced by the virus or chemical in each host species are characterized by completely different karyotypic patterns.
劳斯肉瘤病毒和7,12-二甲基苯并(a)蒽在中国仓鼠和大鼠中诱发的纤维肉瘤与非随机染色体变异有关。尽管在组织学上无法区分,但病毒或化学物质在每种宿主物种中诱发的肿瘤具有完全不同的核型模式。