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The genetic landscape of the childhood cancer medulloblastoma.儿童癌症髓母细胞瘤的遗传特征。
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人类癌症表现出突变型表型：起源、后果和靶向治疗。

Human cancers express mutator phenotypes: origin, consequences and targeting.

机构信息

Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98195, USA.

出版信息

Nat Rev Cancer. 2011 Jun;11(6):450-7. doi: 10.1038/nrc3063. Epub 2011 May 19.

DOI:10.1038/nrc3063
PMID:21593786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4007007/
Abstract

Recent data on DNA sequencing of human tumours have established that cancer cells contain thousands of mutations. These data support the concept that cancer cells express a mutator phenotype. This Perspective considers the evidence supporting the mutator phenotype hypothesis, the origin and consequences of a mutator phenotype, the implications for personalized medicine and the feasibility of ablating tumours by error catastrophe.

摘要

最近关于人类肿瘤 DNA 测序的研究数据表明，癌细胞中含有数千种突变。这些数据支持癌细胞表达突变表型的概念。本观点考虑了支持突变表型假说的证据、突变表型的起源和后果、对个体化医学的影响以及通过错误灾难消融肿瘤的可行性。