人类癌症表现出突变型表型：起源、后果和靶向治疗。
Human cancers express mutator phenotypes: origin, consequences and targeting.
机构信息
Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98195, USA.
出版信息
Nat Rev Cancer. 2011 Jun;11(6):450-7. doi: 10.1038/nrc3063. Epub 2011 May 19.
Abstract
Recent data on DNA sequencing of human tumours have established that cancer cells contain thousands of mutations. These data support the concept that cancer cells express a mutator phenotype. This Perspective considers the evidence supporting the mutator phenotype hypothesis, the origin and consequences of a mutator phenotype, the implications for personalized medicine and the feasibility of ablating tumours by error catastrophe.
摘要
最近关于人类肿瘤 DNA 测序的研究数据表明，癌细胞中含有数千种突变。这些数据支持癌细胞表达突变表型的概念。本观点考虑了支持突变表型假说的证据、突变表型的起源和后果、对个体化医学的影响以及通过错误灾难消融肿瘤的可行性。
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