杆菌肽对甾醇生物合成的抑制作用。
Inhibition of sterol biosynthesis by bacitracin.
作者信息
Stone K J, Strominger J L
出版信息
Proc Natl Acad Sci U S A. 1972 May;69(5):1287-9. doi: 10.1073/pnas.69.5.1287.
Abstract
Bacitracin is an inhibitor of the biosynthesis of squalene and sterols from mevalonic acid, C(5)-isopentenyl pyrophosphate, or C(15)-farnesyl pyrophosphate catalyzed by preparations from rat liver. The antibiotic is active at extremely low ratios of antibiotic to substrate. The mechanism of inhibition appears to be the formation of a complex between bacitracin, divalent cation, and C(15)-farnesyl pyrophosphate and other isoprenyl pyrophosphates. It is similar to the formation of the complex with C(55)-isopropenyl pyrophosphate in microbial systems. The toxicity of bacitracin for animal cells could be due in part to the formation of these complexes.
摘要
杆菌肽是一种由大鼠肝脏制剂催化的、抑制从甲羟戊酸、C(5)-异戊烯基焦磷酸或C(15)-法尼基焦磷酸生物合成角鲨烯和甾醇的物质。该抗生素在抗生素与底物的比例极低时仍具有活性。抑制机制似乎是杆菌肽、二价阳离子与C(15)-法尼基焦磷酸及其他异戊二烯基焦磷酸形成复合物。这类似于在微生物系统中与C(55)-异丙烯基焦磷酸形成复合物的情况。杆菌肽对动物细胞的毒性可能部分归因于这些复合物的形成。
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本文引用的文献
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Bacitracin: an inhibitor of the dephosphorylation of lipid pyrophosphate, an intermediate in the biosynthesis of the peptidoglycan of bacterial cell walls.杆菌肽：一种脂质焦磷酸去磷酸化的抑制剂，脂质焦磷酸是细菌细胞壁肽聚糖生物合成中的一种中间体。
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