细胞松弛素B：对葡萄糖和氨基葡萄糖转运的抑制作用
Cytochalasin B: inhibition of glucose and glucosamine transport.
作者信息
Ebstensen R D, Plagemann P G
出版信息
Proc Natl Acad Sci U S A. 1972 Jun;69(6):1430-4. doi: 10.1073/pnas.69.6.1430.
Abstract
Cytochalasin B has been shown to potently inhibit the transport of glucose, deoxyglucose, and glucosamine by Novikoff hepatoma cells in suspension culture without affecting their intracellular phosphorylation and metabolism. Deoxyglucose transport is inhibited by cytochalasin B in a simple competitive manner. Although this inhibition is not sufficient to explain the biological action of the drug on cytokinesis, it does explain earlier observations on inhibition by cytochalasin B of the incorporation of glucose and glucosamine, and probably of other extracellular precursors, into macromolecules by various types of cells.
摘要
细胞松弛素B已被证明能有效抑制悬浮培养的诺维科夫肝癌细胞对葡萄糖、脱氧葡萄糖和氨基葡萄糖的转运，而不影响其细胞内的磷酸化和代谢。细胞松弛素B以简单的竞争性方式抑制脱氧葡萄糖的转运。尽管这种抑制不足以解释该药物对胞质分裂的生物学作用，但它确实解释了早期关于细胞松弛素B抑制葡萄糖和氨基葡萄糖以及可能其他细胞外前体掺入各种类型细胞的大分子的观察结果。
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