前列腺素F2诱导的唾液分泌以及阿托品和毒扁豆碱对该反应的影响。
Salivation induced by prostaglandin F 2 and modification of the response by atropine and physostigmine.
作者信息
Hahn R A, Patil P N
出版信息
Br J Pharmacol. 1972 Mar;44(3):527-33. doi: 10.1111/j.1476-5381.1972.tb07289.x.
Abstract
- Administration of PGF(2alpha) to the anaesthetized dog produced dose-related salivation accompanied by weak pressor and negative cardiac chronotropic effects. Injection of PGE(1) did not produce salivation.2. Electrical stimulation of the chorda tympani nerve or injection of PGF(2alpha) produced salivary responses which were not affected by pretreatment with phentolamine, but were abolished by pretreatment with atropine. Treatment with hexamethonium reduced the response to nerve stimulation but did not alter the response to PGF(2alpha).3. Pretreatment with physostigmine augmented the salivary response to both nerve stimulation and PGF(2alpha).4. These experiments suggest that salivation produced by PGF(2alpha) is probably due in part, to liberation of acetylcholine from cholinergic nerve terminals. These results are consistent with previously proposed modulatory functions of prostaglandins on neurotransmission.
摘要
- 给麻醉犬注射前列腺素F2α（PGF(2α)）会产生与剂量相关的唾液分泌，同时伴有微弱的升压和负性变时性心脏效应。注射前列腺素E1（PGE(1)）不会产生唾液分泌。2. 电刺激鼓索神经或注射PGF(2α)会产生唾液反应，酚妥拉明预处理不会影响该反应，但阿托品预处理会消除该反应。六甲铵处理会降低对神经刺激的反应，但不会改变对PGF(2α)的反应。3. 毒扁豆碱预处理会增强对神经刺激和PGF(2α)的唾液反应。4. 这些实验表明，PGF(2α)产生的唾液分泌可能部分归因于胆碱能神经末梢释放乙酰胆碱。这些结果与先前提出的前列腺素对神经传递的调节功能一致。
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Salivation induced by prostaglandin F 2 and modification of the response by atropine and physostigmine.前列腺素F2诱导的唾液分泌以及阿托品和毒扁豆碱对该反应的影响。
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