血浆置换术治疗多发性骨髓瘤所致急性肾衰竭
Plasmapheresis in the treatment of acute renal failure in multiple myeloma.
作者信息
Misiani R, Remuzzi G, Bertani T, Licini R, Levoni P, Crippa A, Mecca G
出版信息
Am J Med. 1979 Apr;66(4):684-8. doi: 10.1016/0002-9343(79)91185-9.
PMID:433972
Abstract
Three patients with multiple myeloma and severe acute renal failure were treated by repeated plasmapheresis. Recovery of renal function was observed in all. The pathogenetic role of light chains and the possible mechanisms responsible for renal damage are discussed. It is suggested that the removal of light chains by plasmapheresis may be of therapeutic value in this condition.
摘要
三名患有多发性骨髓瘤和严重急性肾衰竭的患者接受了重复血浆置换治疗。所有患者的肾功能均得到恢复。本文讨论了轻链的致病作用以及导致肾损伤的可能机制。提示血浆置换去除轻链在这种情况下可能具有治疗价值。
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