Rosenblatt S G, Knight W, Bannayan G A, Wilson C B, Stein J H
Am J Med. 1979 Apr;66(4):689-96. doi: 10.1016/0002-9343(79)91186-0.
A case is reported of antiglomerular basement membrane antibody-induced Goodpasture's syndrome in which the patient required hemodialysis and was treated with immunosuppressive agents and plasmapheresis. A severe (80 per cent) cresentic lesion was reversed, and creatinine was stabilized at 2.5 mg/dl at one year follow-up. Earlier reports of therapy without plasmapheresis showed that 88 per cent of the patients would either die or require long-term hemodialysis. Fifteen other reported cases of Goodpasture's syndrome in which the patients were treated with plasmapheresis are reviewed. When reported, short-term follow-up showed that nine of these patients were alive without need of dialysis, five wee receiving dialysis, and only two had died. This suggests that plasmaheresis and immunosuppressive therapy may reverse the renal lesion in some patients with Goodpasture's syndrome.
报告了一例抗肾小球基底膜抗体诱导的肺出血肾炎综合征病例，该患者需要血液透析，并接受了免疫抑制剂和血浆置换治疗。严重的（80%）新月体病变得到逆转，随访一年时肌酐稳定在2.5mg/dl。早期关于未进行血浆置换治疗的报告显示，88%的患者要么死亡，要么需要长期血液透析。回顾了其他15例接受血浆置换治疗的肺出血肾炎综合征报告病例。报告的短期随访结果显示，这些患者中有9人存活且无需透析，5人正在接受透析，只有2人死亡。这表明血浆置换和免疫抑制治疗可能使一些肺出血肾炎综合征患者的肾脏病变得到逆转。
