Wadia N H, Desai M M, Quadros E V, Dastur D K
Br Med J. 1972 Jul 29;3(5821):264-7. doi: 10.1136/bmj.3.5821.264.
Only 20 patients with optic neuritis of unknown aetiology could be collected in Bombay over a period of two and a half years. Only six of them were smokers and only three (one a non-smoker) had bilateral centrocaecal scotomata similar to those found in tobacco amblyopia. In 11 untreated patients the serum vitamin B(12) and plasma thiocyanate levels were estimated and found to show no significant differences from those in normal control subjects. Treatment with hydroxocobalamin in the majority of cases and with cyanocobalamin, corticotrophin, or prednisolone in the rest showed equally good results; spontaneous improvement was seen in one case.No significant role could be assigned to smoking (cyanide) or to vegetarianism in the production of optic neuritis in these patients; nor was there any evidence of depletion of total (cyanide-extracted) B(12) or of an increase in the proportion of non-cyanide-extracted B(12) in the serum.
在孟买，历经两年半的时间，仅收集到20例病因不明的视神经炎患者。其中仅有6人吸烟，只有3人（1人不吸烟）有类似于烟草性弱视所见的双侧中心暗点。对11例未经治疗的患者测定了血清维生素B₁₂和血浆硫氰酸盐水平，发现与正常对照者无显著差异。大多数病例用羟钴胺治疗，其余用氰钴胺、促肾上腺皮质激素或泼尼松龙治疗，结果同样良好；有1例出现自发改善。在这些患者中，吸烟（氰化物）或素食主义在视神经炎的发生中未显示出显著作用；也没有证据表明血清中总（氰化物提取的）B₁₂减少或非氰化物提取的B₁₂比例增加。
