Chisholm I A
Can J Ophthalmol. 1978 Apr;13(2):105-9.
The concentrations of vitamin B12 in the sera from 77 patients diagnosed as suffering from the toxic optic neuropathy associated with tobacco smoking were compared with control levels and with serum folic acid concentrations from the same patients. Of these, 17 patients had associated pernicious anaemia. Serum vitamin B12 levels were significantly lower, whereas the folic acid concentrations showed great variation. Folic acid levels in the serum tended to be high when the vitamin B12 level was low (r = 0.29). The results suggest that the role of folic acid in the genesis of the optic neuropathy is not marked. However persistently low levels of folic acid occurred in one subject and significant clinical improvement resulted only from specific therapy.
对77名被诊断患有与吸烟相关的中毒性视神经病变患者血清中的维生素B12浓度与对照水平以及这些患者的血清叶酸浓度进行了比较。其中，17名患者伴有恶性贫血。血清维生素B12水平显著较低，而叶酸浓度变化很大。当维生素B12水平较低时，血清叶酸水平往往较高（r = 0.29）。结果表明，叶酸在视神经病变发生过程中的作用不明显。然而，有一名患者叶酸水平持续较低，仅通过特异性治疗才取得了显著的临床改善。
