大肠杆菌中需要3',5'-环磷酸腺苷的突变体。
3',5'-cyclic adenosine monophosphate-requiring mutants of Escherichia coli.
作者信息
Onishi Y, Silengo L, Kuwano M, Schlessinger D
出版信息
J Bacteriol. 1972 Sep;111(3):745-9. doi: 10.1128/jb.111.3.745-749.1972.
Abstract
Mutants that require exogenous 3',5'-cyclic adenosine monophosphate (cAMP) for exponential growth were isolated from strains deficient in adenyl cyclase. Studies of one strain showed that cAMP is not incorporated into macromolecules; instead, it seems to have a regulatory function, i.e., in media lacking cAMP, cells form ribonucleic acid (RNA) and protein at linear rather than exponential rates. The exact lesion is not known; ribosomes, messenger RNA, and the beta and beta' subunits of RNA polymerase continue to be made in absence of added cAMP.
摘要
从腺苷酸环化酶缺陷型菌株中分离出了在指数生长期需要外源性3',5'-环磷酸腺苷（cAMP）的突变体。对其中一个菌株的研究表明，cAMP不会掺入大分子中；相反，它似乎具有调节功能，即在缺乏cAMP的培养基中，细胞以线性而非指数速率合成核糖核酸（RNA）和蛋白质。确切的损伤尚不清楚；在不添加cAMP的情况下，核糖体、信使RNA以及RNA聚合酶的β和β'亚基仍会继续合成。
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