3',5'-环磷酸腺苷缺陷型大肠杆菌中己糖转运和盐敏感性的改变
Altered hexose transport and salt sensitivity in cyclic adenosine 3',5'-monophosphate-deficient Escherichia coli.
作者信息
Ezzell J W, Dobrogosz W J
出版信息
J Bacteriol. 1975 Nov;124(2):815-24. doi: 10.1128/jb.124.2.815-824.1975.
Abstract
A cyclic adenosine 3',5'-monophosphate (cAMP)-deficient mutant strain of Escherichia coli K-12 was studied to determine the effect this cyclic nucleotide has on the overall growth and metabolism of this organism. Deficient cells were found to be more susceptible to growth inhibition by salts than were their cAMP-sufficient counterparts. The deficient cells transported alpha-methylglucoside by passive diffusion, whereas the parental cells or mutant cells grown in the presence of exogenous cAMP were able to take up alpha-methylglucoside by the normal active transport process. When viewed together with earlier studies conducted on cAMP-deficient cells, these findings support the view that cAMP plays a key role in regulating the construction and operation of the E. coli membrane system.
摘要
对大肠杆菌K - 12的一种环腺苷酸3',5'-单磷酸（cAMP）缺陷型突变菌株进行了研究，以确定这种环核苷酸对该生物体整体生长和代谢的影响。发现缺陷型细胞比cAMP充足的对应细胞更容易受到盐对生长的抑制作用。缺陷型细胞通过被动扩散转运α-甲基葡萄糖苷，而亲代细胞或在存在外源性cAMP的情况下生长的突变细胞能够通过正常的主动转运过程摄取α-甲基葡萄糖苷。与早期对cAMP缺陷型细胞进行的研究结果相结合，这些发现支持了cAMP在调节大肠杆菌膜系统的构建和运作中起关键作用的观点。
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