Miller V M, South F E
Am J Physiol. 1979 Jan;236(1):R107-16. doi: 10.1152/ajpregu.1979.236.1.R107.
Yellow-bellied marmots, Marmota flaviventris, prepared with U-shaped thermodes in the epidural space of the thoracic vertebral canal, a thermode in the preoptic hypothalamus, and cortical surface and hippocampal electrodes, were used to investigate the interaction of arousal states with temperature regulation. It was found that arousal state of the animal influences the thermoregulatory responses initiated in either the spinal cord or hypothalamus. Further, changes in ambient temperature affected both the gain and the threshold of these responses. The interaction of the hypothalamus and spinal cord was not an additive function, however the threshold for shivering of each could be altered by temperature manipulation of the other. Future studies in modeling of temperature regulation should consider the contributions of temperature receptors of the spinal cord and the arousal state of the animal during the stimulation period.
腹黄旱獭（Marmota flaviventris）被用于研究觉醒状态与体温调节之间的相互作用，其在胸椎管硬膜外腔植入U形热电极，视前下丘脑植入一个热电极，并在皮质表面和海马体植入电极。研究发现，动物的觉醒状态会影响在脊髓或下丘脑启动的体温调节反应。此外，环境温度的变化会影响这些反应的增益和阈值。下丘脑和脊髓之间的相互作用并非简单的叠加功能，然而，通过对另一方进行温度调节，两者的寒颤阈值都可能发生改变。未来关于体温调节建模的研究应考虑脊髓温度感受器的作用以及刺激期间动物的觉醒状态。
