Major L F, Murphy D L, Gershon E S, Brown G L
Am J Psychiatry. 1979 May;136(5):679-84. doi: 10.1176/ajp.136.5.679.
The authors assayed platelet monoamine oxidase (MAO), plasma amine oxidase (AO), and red cell catechol-O-methyl transferase (COMT) in 32 male alcoholics before they began disulfiram treatment. Seven subjects developed psychotic reactions to disulfiram; these 7 had significantly lower pretreatment MAO and AO levels and significantly higher COMT than the patients who had no adverse reactions to disulfiram, which suggests that severe behavioral reactions to disulfiram are associated with differences in enzyme activities.
作者在32名男性酗酒者开始双硫仑治疗前，对其血小板单胺氧化酶（MAO）、血浆胺氧化酶（AO）和红细胞儿茶酚-O-甲基转移酶（COMT）进行了检测。7名受试者对双硫仑产生了精神反应；这7名患者治疗前的MAO和AO水平显著较低，COMT水平显著高于对双硫仑无不良反应的患者，这表明对双硫仑的严重行为反应与酶活性差异有关。
