胆汁酸：肠道中一种pH依赖性抗菌系统？
Bile acids: a pH dependent antibacterial system in the gut?
作者信息
Percy-Robb I W, Collee J G
出版信息
Br Med J. 1972 Sep 30;3(5830):813-5. doi: 10.1136/bmj.3.5830.813.
Abstract
Bile acids are secreted in the bile in the form of conjugates and many species of intestinal bacteria can rapidly deconjugate them. Studies have shown that an unconjugated bile acid may have bactericidal and bacteriostatic effects, which are pH dependent. It is proposed that unconjugated bile acids may be involved in a homoeostatic mechanism, preventing bacterial growth in the small intestine.
摘要
胆汁酸以共轭物的形式分泌到胆汁中，许多肠道细菌种类能够迅速使其去共轭。研究表明，未共轭的胆汁酸可能具有杀菌和抑菌作用，这取决于pH值。有人提出，未共轭的胆汁酸可能参与一种稳态机制，防止细菌在小肠中生长。
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