Kojima S, Hata H, Kobayashi M, Yokogawa M, Takahashi N, Takaso T, Kaneda J
Am J Trop Med Hyg. 1979 Jan;28(1):36-41. doi: 10.4269/ajtmh.1979.28.36.
A patient with eosinophilic meningitis in Shizuoka Prefecture, Honshu, Japan had nausea, vomiting and headache on admission; laboratory examinations revealed leukocytosis with eosinophilia. Eight days later neck stiffness appeared. Lumbar puncture showed an increase of the initial pressure in association with eosinophilic pleocytosis in the spinal fluid. The possibility of angiostrongylosis was considered because the patient had eaten raw slugs for 4 years as a remedy for lumbago. Although the serum contained cross-reactive antibodies against Toxocara canis, positive reactions to Angiostrongylus cantonensis antigens were observed in all of the immunological tests made. These observations, together with results of epidemiological studies in Honshu carried out by other investigators, suggest that the present case of eosinophilic meningitis may have been caused by A. cantonensis. One previous case has been reported from Honshu Island, Japan.
日本本州静冈县一名患有嗜酸性粒细胞性脑膜炎的患者入院时出现恶心、呕吐和头痛；实验室检查显示白细胞增多并伴有嗜酸性粒细胞增多。八天后出现颈部僵硬。腰椎穿刺显示初压升高，同时脑脊液中嗜酸性粒细胞增多。考虑到该患者因腰痛已生食蛞蝓4年，故怀疑有广州管圆线虫病的可能。尽管血清中含有针对犬弓首线虫的交叉反应抗体，但在所有进行的免疫学检测中均观察到对广州管圆线虫抗原的阳性反应。这些观察结果，连同其他研究人员在本州进行的流行病学研究结果，表明本例嗜酸性粒细胞性脑膜炎可能由广州管圆线虫引起。日本本州岛曾报道过1例先前病例。
