Enzenauer R W, Yamaoka R M
Arch Neurol. 1982 Jun;39(6):380-1. doi: 10.1001/archneur.1982.00510180058016.
Central nervous system invasion by helminths is the most frequent cause of eosinophilic pleocytosis in the CSF. Although CSF eosinophilia is an unusual finding in the continental United States, it is not an uncommon observation in cases of meningitis in Hawaii and the South Pacific. The rat lungworm, Angiostrongylus cantonensis has been implicated as the causal agent responsible for cases of eosinophilic meningitis in these areas. The diagnosis of eosinophilic meningitis secondary to A cantonensis is generally an indirect one, based on the characteristic clinical findings, documented eosinophilic pleocytosis of the CSF, and history of consumption of food likely to contain infected larvae. Hydrocephalus developed in a 9-month-old infant from Samoa with absolute eosinophilia and an eosinophilic pleocytosis of the CSF.
蠕虫侵袭中枢神经系统是脑脊液中嗜酸性粒细胞增多最常见的原因。虽然在美国大陆脑脊液嗜酸性粒细胞增多是不常见的发现，但在夏威夷和南太平洋地区的脑膜炎病例中并非罕见。鼠肺线虫，广州管圆线虫被认为是这些地区嗜酸性粒细胞性脑膜炎病例的病原体。继发于广州管圆线虫的嗜酸性粒细胞性脑膜炎的诊断通常是间接的，基于特征性临床表现、脑脊液中嗜酸性粒细胞增多的记录以及食用可能含有感染幼虫食物的病史。一名来自萨摩亚的9个月大婴儿出现了脑积水，伴有绝对嗜酸性粒细胞增多和脑脊液嗜酸性粒细胞增多。
