King R W, Korman M G, Taggart G J, Hansky J
Aust N Z J Surg. 1979 Feb;49(1):129-30. doi: 10.1111/j.1445-2197.1979.tb06459.x.
The effect of intraperitoneal cimetidine, an H2 receptorantagonist, has been assessed on the development of cold-restraint induced acute gastric ulcers in rats. Cimetidine in doses ranging from 20-100 mg per kg body weight significantly reduced the incidence of acute gastric ulceration compared with saline controls in this model. The protective effect of cimetidine suggests a prophylactic role for this agent in stress-induced gastric or duodenal ulceration in man.
已评估了H2受体拮抗剂西咪替丁腹腔注射对大鼠冷束缚诱导的急性胃溃疡形成的影响。在该模型中，与生理盐水对照组相比，每千克体重20 - 100毫克剂量的西咪替丁显著降低了急性胃溃疡的发生率。西咪替丁的保护作用表明该药物在人类应激性胃溃疡或十二指肠溃疡中具有预防作用。
