Lanz E, Sinterhauf K, Knapstein P, Lommer D
Anaesthesist. 1979 Apr;28(4):32-5.
Plasma cortisol was determined by a radioimmuno assay during labour, at and after delivery in 16 primigravidas und epidural anaesthesia and was compared with 13 primigravidas, who delivered under pentazocine or pethidine and pudendal block. Cortisol levels decreased after effective epidural anaesthesia during the first stage of labor and for delivery. They increased in the control patients for delivery and was significantly higher than in the patients under epidural anaesthesia. Two and 20 hours post partum cortisol concentrations decreased in both groups. Cortisol levels in the fetuses and newborns was markedly lower than those of mothers. At delivery, the cortisol concentration of the newborns of both groups was the same. The changes of cortisol concentrations in this study support the conclusion that epidural anaesthesia during labor and delivery reduces stress for the mother, but not for the fetus.
采用放射免疫分析法测定了16例接受硬膜外麻醉的初产妇分娩期间、分娩时及分娩后的血浆皮质醇水平，并与13例接受喷他佐辛或哌替啶及阴部阻滞分娩的初产妇进行了比较。在分娩第一阶段和分娩时，有效的硬膜外麻醉后皮质醇水平下降。对照组产妇在分娩时皮质醇水平升高，且显著高于硬膜外麻醉组产妇。产后2小时和20小时两组皮质醇浓度均下降。胎儿和新生儿的皮质醇水平明显低于母亲。分娩时，两组新生儿的皮质醇浓度相同。本研究中皮质醇浓度的变化支持以下结论：分娩和分娩期间的硬膜外麻醉可减轻母亲的应激，但对胎儿无此作用。
