Pedersen C E, Slocum D R, Robinson D M
Infect Immun. 1972 Nov;6(5):779-84. doi: 10.1128/iai.6.5.779-784.1972.
Small- and large-plaque variants of a Florida strain (Fe 3-7c) of Venezuelan equine encephalomyelitis virus were studied in vivo and in vitro. The small-plaque variant was less virulent in mice, hamsters, and guinea pigs than the large-plaque variant. The variants could be distinguished by calcium phosphate chromatography. The implications of plaque variants within a mixed virus population are discussed.
对委内瑞拉马脑炎病毒佛罗里达毒株(Fe 3 - 7c)的小噬斑和大噬斑变种进行了体内和体外研究。小噬斑变种在小鼠、仓鼠和豚鼠中的毒力低于大噬斑变种。这些变种可用磷酸钙层析法区分。文中讨论了混合病毒群体中噬斑变种的意义。