委内瑞拉马脑炎病毒各亚型对多种实验室宿主的毒力
Virulence of Venezuelan equine encephalomyelitis virus subtypes for various laboratory hosts.
作者信息
Calisher C H, Maness K C
出版信息
Appl Microbiol. 1974 Nov;28(5):881-4. doi: 10.1128/am.28.5.881-884.1974.
Abstract
Mice, guinea pigs, and duck embryo cell cultures were inoculated with known subtypes of Venezuelan equine encephalomyelitis (VEE) virus and the attenuated (TC-83) strain of VEE. With the exception of TC-83, all strains were highly pathogenic for suckling mice by either intracranial or intraperitoneal routes of inoculation used. Virulence for older mice and guinea pigs provided a means to distinguish strains. In addition, virulence or lack of virulence for adult mice or guinea pigs provides a rapid method for separating epizootic subtype IB from TC-83 VEE virus isolates.
摘要
将委内瑞拉马脑炎（VEE）病毒的已知亚型和VEE减毒（TC - 83）株接种到小鼠、豚鼠和鸭胚细胞培养物中。除TC - 83外，所有毒株通过所采用的颅内或腹腔接种途径对乳鼠均具有高度致病性。对大龄小鼠和豚鼠的毒力提供了区分毒株的方法。此外，成年小鼠或豚鼠的毒力或无毒力为从TC - 83 VEE病毒分离株中快速分离流行亚型IB提供了一种方法。
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