Stapleton J V, Austin K L, Mather L E
Anaesth Intensive Care. 1979 Feb;7(1):25-32. doi: 10.1177/0310057X7900700103.
In an attempt to improve postoperative pain management an intravenous infusion of pethidine was designed to provide stable therapeutic blood concentrations. Ten female patients undergoing elective abdominal hysterectomy were studied. After commencement of the infusion, blood pethidine concentrations increased rapidly and exceeded 0.46 microgram/ml after four hours. The mean steady-state concentration of 0.67 microgram/ml was reached by twenty-four hours. This infusion regimen resulted in the abolition of severe pain after three hours and analgesia continued for the duration of the two day study. Significant blood concentrations of the metabolite norpethidine were found although clinically no toxic effects were observed. Side effects of pethidine were infrequent. Controlled continuous intravenous infusion of pethidine produced stable blood concentrations and provided excellent pain control.
为了改善术后疼痛管理，设计了静脉注射哌替啶以提供稳定的治疗性血药浓度。对10名接受择期腹部子宫切除术的女性患者进行了研究。输液开始后，血哌替啶浓度迅速升高，4小时后超过0.46微克/毫升。24小时时达到了0.67微克/毫升的平均稳态浓度。这种输液方案在3小时后消除了剧痛，镇痛持续了为期两天的研究期间。尽管临床上未观察到毒性作用，但发现了代谢产物去甲哌替啶的显著血药浓度。哌替啶的副作用很少见。哌替啶的控制性持续静脉输注产生了稳定的血药浓度并提供了良好的疼痛控制。
