Gilbert C, Galton D J, Kaye J
Br Med J. 1973 Jan 6;1(5844):25-7. doi: 10.1136/bmj.1.5844.25.
An obese patient was studied whose adipose tissue showed a significant reduction in release of glycerol (P < 0.05) when stimulated by isoprenaline despite normal rises in tissue levels of cyclic-AMP. However, lipolysis was stimulated by a fast of 14 days as judged by weight loss and a rise in plasma fatty acids from 0.4 to 1.2 mM. The defect in this patient may be familial since her obese daughter also showed diminished release of glycerol from adipose tissue on three occasions when stimulated by isoprenaline, despite normal rises in levels of cyclic-AMP.
对一名肥胖患者进行了研究，该患者的脂肪组织在受到异丙肾上腺素刺激时，甘油释放量显著减少（P < 0.05），尽管组织中环磷酸腺苷水平正常升高。然而，通过体重减轻以及血浆脂肪酸从0.4 mM升至1.2 mM判断，14天的禁食刺激了脂肪分解。该患者的缺陷可能具有家族性，因为她肥胖的女儿在三次受到异丙肾上腺素刺激时，脂肪组织的甘油释放量也减少，尽管环磷酸腺苷水平正常升高。
