Arner P, Ostman J
Diabetologia. 1976 Dec;12(6):593-9. doi: 10.1007/BF01220636.
Subcutaneous adipose tissue was obtained from 9 patients with untreated diabetes mellitus and from 13 obese nondiabetics. After incubation with isoprenaline or noradrenaline, glycerol release and tissue cyclic AMP (cAMP) were determined. Basal glycerol release was twice as rapid from the diabetic adipose tissue. With isoprenaline, the cAMP concentration and the glycerol production was significantly higher in the diabetic adipose tissue. Noradrenaline did not increase glycerol production or cAMP concentration in the diabetic adipose tissue. Subcutaneous adipose tissue was also removed from the diabetics after antidiabetic treatment. Basal lipolysis was significantly reduced and noradrenaline significantly increased both glycerol release and cAMP production. With isoprenaline, cAMP production and glycerol release were significantly less after antidiabetic treatment than in the untreated state. The data provide evidence for increased alpha- as well as beta-adrenergic receptor sensitivity in human subcutaneous adipose tissue of untreated diabetic patients.
从9例未经治疗的糖尿病患者和13例肥胖非糖尿病患者身上获取皮下脂肪组织。与异丙肾上腺素或去甲肾上腺素孵育后，测定甘油释放量和组织环磷酸腺苷（cAMP）。糖尿病脂肪组织的基础甘油释放速度是正常的两倍。使用异丙肾上腺素时，糖尿病脂肪组织中的cAMP浓度和甘油生成量显著更高。去甲肾上腺素不会增加糖尿病脂肪组织中的甘油生成量或cAMP浓度。糖尿病患者接受抗糖尿病治疗后也切除了皮下脂肪组织。基础脂解作用显著降低，而去甲肾上腺素显著增加了甘油释放量和cAMP生成量。使用异丙肾上腺素时，抗糖尿病治疗后的cAMP生成量和甘油释放量显著低于未治疗状态。这些数据为未经治疗的糖尿病患者的人体皮下脂肪组织中α-和β-肾上腺素能受体敏感性增加提供了证据。
