小鼠多瘤病毒致癌作用的免疫控制

Gaugas J M, Allison A C, Chesterman F C, Rees R J, Hirsch M S

Br J Cancer. 1973 Jan;27(1):10-7. doi: 10.1038/bjc.1973.2.

Adult CBA mice thymectomized, treated with antilymphocytic globulin (ALG) and inoculated with human leprosy organisms were accidentally infected with polyoma virus and all developed tumours. After cessation of ALG administration, some animals were given spleen cells from syngeneic donors immunized with polyoma virus; none developed tumours. Similar results were obtained in mice deliberately infected with polyoma virus but not with leprosy organisms. Passive transfer of antibody before but not after virus inoculation prevented tumour formation in immunosuppressed recipients. Virus infection in thymectomized, lethally irradiated and bone marrow reconstituted mice resulted in only a very low incidence of tumours. These results emphasize the role of immunological surveillance in preventing polyoma tumour formation under natural conditions.

成年CBA小鼠经胸腺切除、抗淋巴细胞球蛋白（ALG）处理并接种人麻风杆菌后，意外感染了多瘤病毒，全部发生了肿瘤。在停止给予ALG后，一些动物被给予来自用多瘤病毒免疫的同基因供体的脾细胞；无一发生肿瘤。在故意感染多瘤病毒但未感染麻风杆菌的小鼠中也获得了类似结果。在病毒接种前而非接种后进行抗体的被动转移可防止免疫抑制受体发生肿瘤形成。在胸腺切除、致死性照射并骨髓重建的小鼠中，病毒感染仅导致很低的肿瘤发生率。这些结果强调了免疫监视在自然条件下预防多瘤肿瘤形成中的作用。