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Design, synthesis, and broad spectrum antiviral activity of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide and related nucleosides.

作者信息

Witkowski J T, Robins R K, Sidwell R W, Simon L N

出版信息

J Med Chem. 1972 Nov;15(11):1150-4. doi: 10.1021/jm00281a014.

DOI:10.1021/jm00281a014
PMID:4347550
Abstract
摘要

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1
Design, synthesis, and broad spectrum antiviral activity of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide and related nucleosides.1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺及相关核苷的设计、合成与广谱抗病毒活性
J Med Chem. 1972 Nov;15(11):1150-4. doi: 10.1021/jm00281a014.
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Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide.病毒唑的广谱抗病毒活性：1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺。
Science. 1972 Aug 25;177(4050):705-6. doi: 10.1126/science.177.4050.705.
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Synthesis and antiviral acticity of some phosphates of the broad-spectrum antiviral nucleoside, 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin).广谱抗病毒核苷1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺（利巴韦林）的某些磷酸盐的合成与抗病毒活性
J Med Chem. 1978 Aug;21(8):742-6. doi: 10.1021/jm00206a005.
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In vitro effect of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (virazole, ICN 1229) on deoxyribonucleic acid and ribonucleic acid viruses.1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺（病毒唑，ICN 1229）对脱氧核糖核酸病毒和核糖核酸病毒的体外作用
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Synthesis and antiviral activity of certain thiazole C-nucleosides.某些噻唑 C-核苷的合成及其抗病毒活性
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Effect of 1-beta-D-ribofuranosyl1-1,2,4-triazole-3-carboxamide (virazole, ICN 1229) on herpes and vaccinia keratitis and encephalitis in laboratory animals.1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺（病毒唑，ICN 1229）对实验动物疱疹性和牛痘性角膜炎及脑炎的作用
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Design, Synthesis, and Antiviral Activity of Novel Ribonucleosides of 1,2,3-Triazolylbenzyl-aminophosphonates.1,2,3-三唑基苄基氨基膦酸酯新型核糖核苷的设计、合成及抗病毒活性
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[Comparative evaluatio of the antiviral activity of the antibiotic rubomycin-complex and its components B and C].[抗生素柔红霉素复合物及其组分B和C的抗病毒活性比较评估]
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Synthesis and biological activity of certain 1,2,3-triazole carboxamide nucleosides related to bredinin and pyrazofurin.与布累迪宁和吡唑呋林相关的某些1,2,3-三唑甲酰胺核苷的合成及生物活性
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Synthesis of tetrazole ribonucleosides and their evaluation as antiviral agents. 2. 5-Amino-1-(beta-D-ribofuranosyl)-1H-tetrazole and 5-amino-2-(beta-D-ribofuranosyl)-2H-tetrazole.四唑核糖核苷的合成及其作为抗病毒剂的评价。2. 5-氨基-1-(β-D-呋喃核糖基)-1H-四唑和5-氨基-2-(β-D-呋喃核糖基)-2H-四唑。
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