Buńag R, Mullenix P
Br J Pharmacol. 1972 Nov;46(3):511-3. doi: 10.1111/j.1476-5381.1972.tb08149.x.
The effects of amobarbital anaesthesia on blood pressure responses to angiotensin and noradrenaline were determined in rats with chronically implanted venous and aortic catheters. Responses were tested twice on the same day in each rat, first in the conscious state and then during anaesthesia. Blood pressure rises produced by noradrenaline and angiotensin were larger when the rats were anaesthetized with amobarbital than when they were conscious. This enhancement was not characteristic of general anaesthesia since urethane, instead of enhancing, depressed the pressor responses.Blockade of acetylcholine receptors with atropine also increased the response to pressor drugs. However, amobarbital in anaesthetic doses did not affect the response to acetylcholine, indicating that removal of compensatory parasympathetic reflexes was not a major cause of its enhancing effect. The effects of amobarbital on arterial pressure and heart rate were similar to those of the ganglion blocking drug pentolinium. When pressor responses were increased by amobarbital, autonomic ganglia were depressed as indicated by the loss of the response to nicotine. These findings suggest that amobarbital enhances blood pressure responses to noradrenaline and angiotensin by blocking autonomic ganglia.
在长期植入静脉和主动脉导管的大鼠中，测定了异戊巴比妥麻醉对血压对血管紧张素和去甲肾上腺素反应的影响。在同一天对每只大鼠进行两次反应测试，首先在清醒状态下，然后在麻醉状态下。用异戊巴比妥麻醉的大鼠，去甲肾上腺素和血管紧张素引起的血压升高比清醒时更大。这种增强并非全身麻醉的特征，因为氨基甲酸乙酯非但增强反而抑制了升压反应。用阿托品阻断乙酰胆碱受体也增加了对升压药的反应。然而，麻醉剂量的异戊巴比妥并不影响对乙酰胆碱的反应，这表明消除代偿性副交感反射不是其增强作用的主要原因。异戊巴比妥对动脉血压和心率的影响与神经节阻断药潘托铵相似。当异戊巴比妥增加升压反应时，如对尼古丁反应的丧失所示，自主神经节受到抑制。这些发现表明，异戊巴比妥通过阻断自主神经节增强血压对去甲肾上腺素和血管紧张素的反应。
