在给予各种麻醉剂之前和之后大鼠对去甲肾上腺素的心血管反应。
Cardiovascular responses to noradrenaline in the rat before and after administration of various anaesthetics.
作者信息
Brezenoff H E
出版信息
Br J Pharmacol. 1973 Dec;49(4):565-72. doi: 10.1111/j.1476-5381.1973.tb08531.x.
Abstract
- Cardiovascular responses to intravenously administered noradrenaline were monitored in the rat in the conscious state and again following anaesthesia. Injections and pressure recordings were made via permanently implanted venous and arterial catheters.2. The pressor response to noradrenaline was inhibited by diethyl ether, urethane and deep pentobarbitone anaesthesia. It was unchanged by ketamine and was potentiated by chloralose and light pentobarbitone anaesthesia.3. Reflex bradycardia was potentiated by chloralose, blocked by ketamine and reduced by pentobarbitone. It was either reduced or unchanged by ether or urethane.
摘要
在清醒状态下对大鼠静脉注射去甲肾上腺素后的心血管反应进行监测，然后再次在麻醉状态下监测。通过永久植入的静脉和动脉导管进行注射和压力记录。
去甲肾上腺素的升压反应在乙醚、乌拉坦和深度戊巴比妥麻醉下受到抑制。在氯胺酮麻醉下无变化，在氯醛糖和浅度戊巴比妥麻醉下增强。
反射性心动过缓在氯醛糖麻醉下增强，在氯胺酮麻醉下被阻断，在戊巴比妥麻醉下减弱。在乙醚或乌拉坦麻醉下则减弱或无变化。
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