Reynolds L R, Bhathena D
Arch Intern Med. 1979 Feb;139(2):236-7.
Thionamide drugs are widely used in the management of hyperthyroidism and are infrequently associated with adverse reactions. We report the development of the nephrotic syndrome during methimazole (Tapazole) therapy in a young man with Graves' disease. His proteinuria remitted promptly with discontinuance of the drug, and renal histologic features bore a striking resemblance to the toxic nephrosis induced in animals by the aminonucleoside of puromycin. In view of the histologic similarities, we propose that methimazole acted as a direct glomerular toxin, inducing the nephrotic syndrome in this patient.
硫酰胺类药物广泛用于甲状腺功能亢进症的治疗，且不良反应较少。我们报告了1例患有格雷夫斯病的年轻男性在接受甲巯咪唑（他巴唑）治疗期间发生肾病综合征。停用该药物后，他的蛋白尿迅速缓解，肾脏组织学特征与嘌呤霉素氨基核苷诱导的动物中毒性肾病极为相似。鉴于组织学上的相似性，我们认为甲巯咪唑作为一种直接的肾小球毒素，在该患者中诱发了肾病综合征。
